Rock Band 3 isn't the only game integrating a real guitar into a music game.
If you had asked me prior to E3 what Power Gig: Rise of the SixString was, I would've looked at you in complete confusion. As I came to learn on the last day of the show, Power Gig is actually a music game, and similar to Rock Band 3, the game works in the use of a real-deal guitar.