In Scribblenauts, Death beats God, God beats Cthulu, and Cthulu beats Death.
A lot of the buzz said that Scribblenauts was something unlike anything anyone had seen before. I think I even heard rumors coming out of E3 that if you typed "Cure Cancer" into the game you would actually cure cancer. In the grand scheme of things, though, Scribblenauts isn't a perfect cancer-curing video game, but it still has one of the most innovative ideas I've ever seen in a video game.